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Dernière mise à jour : Mai 2018

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ASSEMBILES

Towards an optimization of the absorption of lipophilic micro-constituents via the intestinal assemblies formed according to the type and quantity of ingested lipids.

ANR générique
The objective of the project is to understand the role of the type of fatty acid and of monoglyceride (triglyceride digestion products) on the structure of the assemblies of bile-lipids and on their capacity to solubilize lipophilic micro-constituents, and how these lipophilic structures influence in vitro and in vivo absorption of these compounds.
Mixed assemblages (micellar but also lamellar ...) composed of lipids and bile salts are formed during digestion, and are responsible for the transport of lipids and lipophilic micro-constituents such as A, E, D, K vitamins, carotenoids and sterols. But the determinants of their solubilization capacity (the amount they can incorporate) are not well known.
The aim of the project is to understand the role of the type of fatty acid and of monoglyceride (triglyceride digestion products) on the structure of the assemblies of bile-lipids and on their capacity to solubilize lipophilic micro-constituents, and how these lipophilic structures influence in vitro and in vivo absorption of these compounds.
The comparison of the experimental and modeled results will make it possible to predict the effect of the structure and the type of lipid of the assemblies on the absorption of numerous classes of lipophilic micro-constituents.
ANR Assembiles
  • Project duration : 36 months (November 2018-October 2021)
  • Coordination : Sébastien Marze (BIA Unit - ISD team)
  • Academic partners:
    • INRA – BIA
    • Centre de recherche en cardiovasculaire et nutrition (C2VN)
    • Ingénierie, Procédés, Aliments (GENIAL)
    • Institut de Physique de Rennes (IPR)
  • Total budget : 228 787 €