Ticks and tick-Borne Diseases (TiBoDi)
To characterize the interactions among the players involved in tick-borne diseases and their genetic variability to propose new control methods.
Context and issues
- Major role of ticks in animal but also human health as most tick-borne diseases – the main vector borne diseases in our latitudes – are zoonotic.
- Epidemiology of tick-borne diseases is influenced by agriculture through :
- Its action on spatial organization of the different biotopes within agro-ecosystems.
- The involvement of livestock as hosts for tick feeding and potential reservoir for pathogenic agents.
- Characterize the genome and the genetic variability of ticks and the microorganisms they carry to :
- understand their evolution,
- estimate their dispersal,
- evaluate their host specificity,
- study the genes involved in life history traits influencing the epidemiology of thoses diseases,
- identify potential target for the development of new control methods (acaracides, antiprotozoal, vaccines, antisymbiotic drugs…).
- Understand the eco-epidemiology of tick borne diseases through a better knowledge of the ecology of ticks (population dynamics, ecological preferences…), their hosts and the microorganisms they carry.
- Ticks (especially Ixodes ricinus)
- Protozoa (especially Babesia)
- Bacteria (especially the symbiont Midichloria mitochondrii)
- Vertebrates used by ticks as hosts (domestic animals and wildlife)
- Zoonotic diseases
- Tick borne diseases
- Host-parasite interactions
Expertise and skills
- Evolutionary Biology (population genetics, phylogeography, phylogeny…)
- Taxonomy (Ixodida, Apicomplexa)
- Biology-Modelisation interface
- Xenobio-Tick : Transcriptomic and functional characterization of tick specific neuroreceptors that will constitute targets for the development of innovative acaricides
- GenIric : whole Genome sequencing of the tick Ixodes ricinus, vector of multiple human and animal
- CC-EID : Climate-Change and the risk of Emergence of wildlife-borne Infectious Diseases in agricultural and forest landscapes